It's meeeee

LoL

Fri, 24 Dec 2010 13:48:51 -0500

LoL

lol

Wed, 22 Dec 2010 03:24:19 -0500

lol

Photo

Wed, 22 Dec 2010 01:13:18 -0500

DANGER

Tue, 21 Dec 2010 23:21:50 -0500

DANGER

fuckyeah-awesome-stuff: Via http://www.phoolish.com Follow...

Thu, 16 Dec 2010 16:31:28 -0500

fuckyeah-awesome-stuff:

Via http://www.phoolish.com

Follow Now | Facebook Like It

(via fuckyeahfunnythings)

Yahoo is shutting down delicious!

Thu, 16 Dec 2010 16:12:46 -0500

At an all-hands meeting for the Yahoo product team following a round of layoffs yesterday that significantly impacted that group, EVP of Americas Ross Levinsohn and Chief Product Officer Blake Irving announced plans to “sunset” eight products and consolidate others.

Products to be shut down include MyBlogLog, Yahoo Picks, AltaVista, Yahoo Bookmarks, Yahoo Buzz and Delicious. Some of those came from acquisitions and others were internally generated.

The news first came out via a screenshot of the webcast posted on Twitter by Eric Marcoullier that includes a slide with a list of impacted products next to an image of Levinsohn and Irving announcing the news. Marcoullier was founder of MyBlogLog, which created one of the products being shut down. (MyBlogLog was bought by Yahoo in 2007 and pretty much neglected ever since.)

The slide also shows plans to merge additional products, including Fire Eagle and Yahoo People Search, and make features out of many others, including Yahoo Alerts and Yahoo Calendar. (If you have better eyes than I, please help identify some of those logos in the comments.)

Marcoullier is no longer at Yahoo, though the validity of his webcast screenshot was confirmed when he was quickly criticized on Twitter by various current Yahoo employees who didn’t appreciate it getting out, including Irving himself. Irving insinuated he would fire whoever leaked the webcast.

While the layoffs and shutdowns obviously indicate a deemphasis of technology products by Yahoo, they aren’t necessarily unwarranted. Some of these products were the same as those mentioned on then-SVP Brad Garlinghouse’s infamous Peanut Butter Memo way back in 2006 as candidates for streamlining.

http://www.thoughtmechanics.com/yahoo-to-shut-down-buzz-delicious-mybloglog-and-others/

Stem cell transplant has cured HIV!

Thu, 16 Dec 2010 08:17:08 -0500

WASHINGTON (AFP) - An American man is still HIV-free more than three years after receiving a stem cell transplant, suggesting the first cure has been found for the virus that causes AIDS, German doctors said Wednesday.

While the highly lethal technique used on the man known as the “Berlin Patient” would not work for most of the 33 million people with HIV worldwide, scientists say the research shows important progress toward a universal cure.

“Our results strongly suggest that cure of HIV has been achieved in this patient,” said the study in the peer-reviewed journal Blood, a publication of the American Society of Hematology.

The process began in 2006 when a US man in his 40s, who had been HIV positive for more than a decade, sought treatment for acute myeloid leukemia, a lethal blood cancer.

After a first round of chemotherapy failed, his German doctor, Gero Hutter, thought he would see if he could perform a bone marrow transplant using a donor with a rare genetic mutation that is naturally resistant to HIV.

About one in 100 Caucasian people, or one percent of the population, have the mutation which prevents the molecule CCR5 from appearing on the cell surface.

Since HIV enters the cell through CCR5 molecules, when they are absent HIV cannot penetrate.

The process was not easy, but after rejecting dozens of potential donors Hutter finally found a match and performed the bone marrow transplant using stem cells from the HIV-resistant donor in February 2007.

Hutter’s first study, published in the New England Journal of Medicine in 2009, showed no sign that HIV had re-emerged even though the patient had ceased anti-retroviral therapy to suppress HIV.

The latest findings show that, three years later, the patient continues to show no trace of either the AIDS-causing virus or leukemia.

But given that around 30 percent of patients die when attempting bone marrow transplants, AIDS experts sounded a note of caution.

“I think we need a lot more research to try to replicate this without putting a patient’s life in danger,” said Karen Tashima, director of the HIV Clinical Trials Program at The Miriam Hospital in Rhode Island.

“Since we have good anti-retroviral therapy that can control the virus, it would be unethical to give somebody such an extreme treatment.”

Lead study author Kristina Allers acknowledged that the process would not work for most people.

“Nevertheless, as the study tells us that HIV cure is in principle possible, it gives new hope for scientists in the HIV cure research,” Allers said.

“So the next challenge is to translate our findings into a strategy that can be applied without being life-threatening.”

Indeed, US researchers are already working on ways to replicate the same process in the cells without going the same risky route.

“I am very excited about it,” said David Baltimore, a co-recipient of the Nobel Prize in Medicine in 1975.

Baltimore is the founder of a biotech company that is working on developing its own stem-cell HIV/AIDS therapy that works functionally the same as the German team’s, and is in the process of organizing clinical trials, he said.

“What we are trying to do is treat a patient’s own cells so there is no immunological problem,” he said.

“The fact that the one patient who was treated then was effectively cured is I think a very strong argument that you want to continue this kind of approach to the HIV problem.”

Jay Levy, an AIDS and cancer researcher at the University of California, San Francisco, described the latest research as evidence of a “functional cure.”

“I mean, one person is not sufficient. It is an encouraging first step but you really need to show it again,” he said.

“I always look on this as a direction for future approaches, recognize what the problems are and then see if we can do better, and I have faith in my scientific colleagues to come up with something better.”

Levy and his team are also looking at ways to manipulate a patient’s own stem cells so that they do not express the receptors that allow HIV infection, much like the CCR5 mutation.

“Three years is not enough… We will know that in 10 years,” said Levy regarding the study’s assertion that a cure has been found.

“It is too early to say you’ve cured, but my Lord, they have done a nice job.”

15 MB Hard Drive for $2500?!? Oh how far we have come!...

Thu, 16 Dec 2010 07:09:00 -0500

15 MB Hard Drive for $2500?!? Oh how far we have come! Think about it…this is enough to hold like 2 or 3 MP3s

http://fortheluls.com/2010/12/16/15mb-hd-for-2495/

HAHA what a cite little kid!

Thu, 16 Dec 2010 05:31:12 -0500

HAHA what a cite little kid!

LEAVE BRITTNEY ALONE!!!!!

Thu, 16 Dec 2010 05:30:21 -0500

LEAVE BRITTNEY ALONE!!!!!

image from carandcrasher.com

Thu, 16 Dec 2010 05:28:34 -0500

image from carandcrasher.com

Photo

Tue, 14 Dec 2010 21:53:46 -0500

iamhack: BEST APOLOGY EVER

Tue, 14 Dec 2010 19:50:25 -0500

iamhack:

BEST APOLOGY EVER

naplesguy: This would make for a great motivational picture,...

Tue, 14 Dec 2010 19:35:51 -0500

naplesguy:

This would make for a great motivational picture, it’s just missing the words lol

Photo

Sun, 12 Dec 2010 10:14:44 -0500

How to Choose a Good Web Design Company

Wed, 08 Dec 2010 18:58:00 -0500

Individuals, business owners, NGOs, government, all understand the need of a website. If you do not have one yet and have decided that this is the time to take the plunge, or if you need to redesign your existing site, deciding “who” would be doing it is a crucial decision.

Most small and even mid size business owners do not have the knowledge and expertise to design and develop a website on their own. If you are one such soul, the point below can make life easier for you by thinking on some points that you need to mull over before you decide whom to hire. Remember that a poorly designed website can not only ruin your brand but can also drive customers away from you. Follow the steps mentioned below and your odds of finding a technology savvy, creative, responsive and cost efficient design firm will go up significantly.

See their past work

Definitely, proof of the pudding lies in its taste but it is you who will have to pay for the cooking and the cook, both. Why not just see what the design company is capable of producing by seeing some of their past work? Also, ensure that the work has been done by themselves and not by some third party or even worse, they have not taken someone else’s work and show to you as theirs. Ask them for phone numbers, emails and real client names whom you can contact to confirm their work standards and delivery norms.

Work Examples in Different Industries

An extension of the point above, but this one makes a big difference. Does their layout, structure, navigation, typography, all look similar across websites? If yes, what is the reason? Are they using some cheap template and modifying it or are the genuinely non creative? Go ahead with them if the answer to the above question is a resounding “No”!

Responsiveness

If the business development managers are not responding in the initial talks, it is a good sign that the organization structure is either messed up or they care little. Also, look for their choice of response tool. Do they love emailing or do they ever call? How do they do project management? How would the mockups be approved or the feedback given? The web design industry is one of the most advanced industries online and in the era of Basecamp, activCollab and ProofHQ, if they are still going for email based approvals, we suggest run, as fast as you can and in opposite direction from them.

What is in written?

Agreements and requirement discussions over email, phone and in person are all OK, but everything decided should be presented in a formal contract. Are they putting up a contract, a work order or not? If yes, go through the entire contract, terms and conditions, what’s not covered paragraphs and other minute details carefully. Else it would be easy for a designer to take you hostage through the contract, which you never read in entirety.

Pricing

This is the double edged sword and it usually lives up to this comparison to tear you apart. As a customer, you always would be on a prowl for the best value for your money. But do not confuse this with the cheapest option. There are many “package options” available which can sell you as cheap as $500 for a website. There may be many catches in it like use of cheap templates, non deliverability of programming portions, buggy code and so on and so forth.

Ensure that you set aside funds which should be invested in the development of your website regularly. If you are short on cash, it is better to settle for a small but custom design and as cash flow improves, invest some funds to improve the site further.

Can they Market your Website?

From most of the design firms, you would get a response – “Oh Yes, we do SEO too!” Do not get convinced without seeing a couple of things like customers that they have done SEO/PPC/SMO for, their own rankings on search engines and client testimonials if possible. Ask some penetrating questions on topics like SEO and if they mention 300 search engines submitted to and reciprocal link exchange, either look for a different designer or at least do not give your SEO to them.

Time of delivery

As important as the price for designing, this attribute usually gets overlooked by clients. In service industry, it is possible that the service provider is juggling with tons of clients at the same time. Would they be able to devote their best teams? Would they be in a position to QA everything properly? Would co-ordination between the design and development be smooth enough without any hiccups?

Technology Prowess

Web design and development is a fast paced industry and it is possible (and fair too) that you do not know everything about the technology. Still, searching and researching about the solutions that they suggest for content management, site management, image management would be good to know. Would their design confirm to web standards? Would the site be completely spiderable by the search engine robots? These questions can help you go a long way and get the best for your website at least from a technology perspective.

from: TM web design company & website design naples

I’ve had just about enough of your bullshit.

Wed, 08 Dec 2010 18:37:34 -0500

I’ve had just about enough of your bullshit.

I don’t even know…

Wed, 08 Dec 2010 05:14:56 -0500

I don’t even know…

Shut your whore mouth when Billy Mays is talking!

Wed, 08 Dec 2010 05:12:00 -0500

Shut your whore mouth when Billy Mays is talking!

Virginity lol

Wed, 08 Dec 2010 05:11:00 -0500

Virginity lol